Definition of Cereblon. Meaning of Cereblon. Synonyms of Cereblon

Here you will find one or more explanations in English for the word Cereblon. Also in the bottom left of the page several parts of wikipedia pages related to the word Cereblon and, of course, Cereblon synonyms and on the right images related to the word Cereblon.

Definition of Cereblon

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Meaning of Cereblon from wikipedia

- Cereblon is a protein that in humans is encoded by the CRBN gene. The gene that encodes the cereblon protein is found on the human chromosome 3, on the...
- Cereblon E3 ligase modulators, also known as immunomodulatory imide drugs (IMiDs), are a class of immunomodulatory drugs (drugs that adjust immune responses)...
- belongs to a class of drugs known as immunomodulatory imide drugs (IMiDs) or Cereblon E3 ligase modulators, which includes thalidomide and its analogs. In lymphocytes...
- in both their anti-cancer and teratogenic effects is now known to be as cereblon E3 ligase modulators. Thalidomide also binds to and acts as an antagonist...
- Mezigdomide is a cereblon E3 ligase modulator developed by Bristol Myers Squibb to treat multiple myeloma. Richardson, Paul G.; Trudel, Suzanne; Quach...
- and anti-myeloma activities. Like thalidomide, pomalidomide works as a cereblon E3 ligase modulator. Pomalidomide can cause harm to unborn babies when...
- Room (Press release). 2022-01-13. Retrieved 2023-05-23. "SP-3164, a Novel Cereblon-Binding Protein Degrader, Shows Activity in Preclinical Lymphoma Models"...
- Iberdomide is an experimental thalidomide analog that works as an cereblon E3 ligase modulator; it has a higher binding affinity than lenalidomide or pomalidomide...
- Mitsiades CS, et al. (2014-01-17). "The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins". Science. 343 (6168): 305–309...
- 2010-03-21. As they report in the current issue of Science, a protein known as cereblon latched on tightly to the thalidomide "Thalidomide: The Fifty Year Fight...