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Cereblon is a
protein that in
humans is
encoded by the CRBN gene. The gene that
encodes the
cereblon protein is
found on the
human chromosome 3, on the...
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Cereblon E3
ligase modulators, also
known as
immunomodulatory imide drugs (IMiDs), are a
class of
immunomodulatory drugs (drugs that
adjust immune responses)...
-
belongs to a
class of
drugs known as
immunomodulatory imide drugs (IMiDs) or
Cereblon E3
ligase modulators,
which includes thalidomide and its analogs. In lymphocytes...
- in both
their anti-cancer and
teratogenic effects is now
known to be as
cereblon E3
ligase modulators.
Thalidomide also
binds to and acts as an antagonist...
- Room (Press release). 2022-01-13.
Retrieved 2023-05-23. "SP-3164, a
Novel Cereblon-Binding
Protein Degrader,
Shows Activity in
Preclinical Lymphoma Models"...
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Mezigdomide is a
cereblon E3
ligase modulator developed by
Bristol Myers Squibb to
treat multiple myeloma. Richardson, Paul G.; Trudel, Suzanne; Quach...
- and anti-myeloma activities. Like thalidomide,
pomalidomide works as a
cereblon E3
ligase modulator.
Pomalidomide can
cause harm to
unborn babies when...
-
Iberdomide is an
experimental thalidomide analog that
works as an
cereblon E3
ligase modulator; it has a
higher binding affinity than
lenalidomide or pomalidomide...
- Wang J,
Raina K, et al. (June 2015). "Hijacking the E3
Ubiquitin Ligase Cereblon to
Efficiently Target BRD4".
Chemistry & Biology. 22 (6): 755–763. doi:10...
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Avadomide is an
experimental cereblon E3
ligase modulator, or
thalidomide analog studied to see if it is
effective against cancer. Nishi, Hidemi; Gotoh...
