Definition of Cereblon. Meaning of Cereblon. Synonyms of Cereblon

- Cereblon is a protein that in humans is encoded by the CRBN gene. The gene that encodes the cereblon protein is found on the human chromosome 3, on the...
- Cereblon E3 ligase modulators, also known as immunomodulatory imide drugs (IMiDs), are a class of immunomodulatory drugs (drugs that adjust immune responses)...
- Mezigdomide is a cereblon E3 ligase modulator developed by Bristol Myers Squibb to treat multiple myeloma. Richardson, Paul G.; Trudel, Suzanne; Quach...
- belongs to a class of drugs known as immunomodulatory imide drugs (IMiDs) or Cereblon E3 ligase modulators, which includes thalidomide and its analogs. In lymphocytes...
- Iberdomide is an experimental thalidomide analog that works as an cereblon E3 ligase modulator; it has a higher binding affinity than lenalidomide or pomalidomide...
- in both their anti-cancer and teratogenic effects is now known to be as cereblon E3 ligase modulators. Thalidomide also binds to and acts as an antagonist...
- states. One example is lenalidomide (an immunomodulatory drug), which binds cereblon (CRBN) and reprograms it to degrade transcription factors like IKZF1/IKZF3...
- 2010-03-21. As they report in the current issue of Science, a protein known as cereblon latched on tightly to the thalidomide "Thalidomide: The Fifty Year Fight...
- Avadomide (CC-122) is an experimental cereblon E3 ligase modulator, or thalidomide analog (molecular glue) that was discovered and studied by Celgene to...
- pathogenesis of certain viruses including HIV. A component of a CUL4A complex, Cereblon, was discovered to be a major target of the teratogenic agent thalidomide...