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Castanospermine is an
indolizidine alkaloid first isolated from the
seeds of
Castanospermum australe. It is a
potent inhibitor of some
glucosidase enzymes...
- The
polyhydroxy alkaloids include compounds like
castanospermine and swainsonine. (+)-
Castanospermine (-)-Swainsonine The
primary alkaloids within the...
-
central core of the
indolizidine alkaloids such as
swainsonine and
castanospermine.
Indole Indolizine Tryptophan Tryptamine Skvortsov, I. M.; Zadumina...
- α-aminoadipic acid →
pipecolic acid → 1
indolizidinone Swainsonine,
castanospermine Pyridine derivatives Simple derivatives of
pyridine Nicotinic acid...
- livestock,
environmental GSD is
caused by
intoxication with the
alkaloid castanospermine. However, not
every inborn error of
carbohydrate metabolism has been...
- baway, yiwurra, junggurraa, mirrayn, ganyjuu, and binyjaalga. In 1981,
castanospermine was
isolated from the seeds.
Members of this and
closely related genera...
-
activity was
subsequently observed for swainsonine—a
mannose analogue—and
castanospermine—a
glucose analogue—in the 1980s. More than 200 have now been reported...
- in nature,
including deoxynojirimycin, swainsonine,
australine and
castanospermine. From
these natural templates many
other inhibitors have been developed...
-
acquired environmental GSD is
caused by
intoxication with the
alkaloid castanospermine.)
Metabolic myopathies cause the
underproduction of
adenosine triphosphate...
- C
virus (HCV) infection, is an oral
prodrug of the
natural product castanospermine that
inhibits alpha-glucosidase I, an
enzyme that
plays a critical...
