-
Apoptotic caspases are
subcategorised as:
Initiator Caspases (
Caspase 2,
Caspase 8,
Caspase 9,
Caspase 10)
Executioner Caspases (
Caspase 3,
Caspase 6 and...
- of
caspases:
initiator caspases (
caspases 2, 8, 9, 10, 11, and 12) and
effector caspases (
caspases 3, 6, and 7). The
activation of
initiator caspases requires...
-
called caspases. The
function of
caspase 4 is not
fully known, but it is
believed to be an
inflammatory caspase,
along with
caspase 1,
caspase 5 (and...
-
Caspase-3 is a
caspase protein that
interacts with
caspase-8 and
caspase-9. It is
encoded by the CASP3 gene. CASP3
orthologs have been
identified in numerous...
- acid
protease (
caspase) family.
Sequential activation of
caspases plays a
central role in the execution-phase of cell apoptosis.
Caspases exist as inactive...
-
Caspase-9 is an
enzyme that in
humans is
encoded by the CASP9 gene. It is an
initiator caspase,
critical to the
apoptotic pathway found in many tissues...
- mitochondria-derived
activator of
caspases or SMAC. This
protein binds inhibitor of
apoptosis proteins (IAPs), thus
freeing caspases to
activate apoptosis. Due...
-
Caspase-1/Interleukin-1
converting enzyme (ICE) is an
evolutionarily conserved enzyme that
proteolytically cleaves other proteins, such as the precursors...
- a
different set of
caspases as
compared to apoptosis, for example,
caspase-1/4/5 in
humans and
caspase-11 in mice.
These caspases contribute to the maturation...
-
Caspase recruitment domains, or
caspase activation and
recruitment domains (CARDs), are
interaction motifs found in a wide
array of proteins, typically...
