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Apoptotic caspases are
subcategorised as:
Initiator Caspases (
Caspase 2,
Caspase 8,
Caspase 9,
Caspase 10)
Executioner Caspases (
Caspase 3,
Caspase 6 and...
- of
caspases:
initiator caspases (
caspases 2, 8, 9, 10, 11, and 12) and
effector caspases (
caspases 3, 6, and 7). The
activation of
initiator caspases requires...
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Caspase-3 is a
caspase protein that
interacts with
caspase-8 and
caspase-9. It is
encoded by the CASP3 gene. CASP3
orthologs have been
identified in numerous...
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Caspase recruitment domains, or
caspase activation and
recruitment domains (CARDs), are
interaction motifs found in a wide
array of proteins, typically...
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Caspase-9 is an
enzyme that in
humans is
encoded by the CASP9 gene. It is an
initiator caspase,
critical to the
apoptotic pathway found in many tissues...
- a
different set of
caspases as
compared to apoptosis, for example,
caspase-1/4/5 in
humans and
caspase-11 in mice.
These caspases contribute to the maturation...
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Caspase-8 is a
caspase protein,
encoded by the CASP8 gene. It most
likely acts upon
caspase-3. CASP8
orthologs have been
identified in
numerous mammals...
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Activation and ****embly of the
inflammasome promotes the
activation of
caspase-1,
which then
proteolytically cleaves pro-inflammatory cytokines, interleukin...
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Caspase 14 is an
enzyme that in
humans is
encoded by the CASP14 gene.
Orthologs of this gene also
exist in
other mammals, such as
sirenians and cetaceans...
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Caspase-1/Interleukin-1
converting enzyme (ICE) is an
evolutionarily conserved enzyme that
proteolytically cleaves other proteins, such as the precursors...
