-
human DNA
polymerases alpha, beta, and
gamma by the 5'-triphosphates of
carbovir, 3'-azido-3'-deoxythymidine, 2',3'-dideoxyguanosine and 3'-deoxythymidine...
-
candidates at UMN,
where he went on to
develop carbocyclic nucleosides termed '
carbovirs.' This
class of
medicinal agents included the drug abacavir. Abacavir...
- The (-)
enantiomer of
carbovir was
later shown to be the
biologically active form for
inhibition of HIV.
However carbovir's low
aqueous solubility and...
-
viral replication. It is a
guanosine analogue that is
phosphorylated to
carbovir triphosphate (CBV-TP). CBV-TP
competes with the
viral molecules and is...
- in mind,
including carbocyclic puromycin (I),
carbocyclic Ara-A (II),
carbovir (III) and
guanine as well as
azaguanine carbocyclic derivatives (IV) Vince...
- Minnesota,
where he went on to
develop carbocyclic nucleosides termed '
carbovirs'. This
class of
medicinal agents included the drug abacavir. Abacavir...
- the
monophosphate is
converted to
carbovir 3ยด-monophosphate. Subsequently, it is
fully phosphorylated and the
carbovir is
incorporated by the RT into the...
