- The
calicheamicins are a
class of
enediyne antitumor antibiotics derived from the
bacterium Micromonospora echinospora, with
calicheamicin γ1
being the...
-
antitumor antibiotic calicheamicin (N-acetyl-γ-
calicheamicin)
payload via a
bifunctional linker (4-(4-acetylphenoxy)butanoic acid).
Calicheamicin (the payload)...
-
against CD22 (inotuzumab),
linked to a
cytotoxic agent from the
class of
calicheamicins called ozogamicin. The US Food and Drug
Administration (FDA) considers...
-
during a
search for new
anticancer products produced by microorganisms.
Calicheamicin was one of the
first such
products identified and was
originally found...
- G.A. Ellestad; D.
Kahne (1992). "Cleavage
behavior of
calicheamicin gamma 1 and
calicheamicin T". Proc Natl Acad Sci USA. 89 (10): 4608–12. Bibcode:1992PNAS...
-
river Styx (modern-day
Mavroneri in Arcadia, Greece) that
contained calicheamicin, a
dangerous compound produced by bacteria.
Several natural causes (diseases)...
-
studied compound in this class.
Esperamcin A1 and the
related enediyne calicheamicin are the two most
potent antitumor agents known. The
esperamicins are...
- gentamicin, mutamicin, netilmicin, retymicin, sisomicin, verdamicin,
calicheamicin, and the
recently found turbinmicin.
Potent new
antifungal drugs discovered...
-
covalently attached to the
cytotoxic antitumor antibiotic calicheamicin (N-acetyl-γ-
calicheamicin) via a
bifunctional linker (4-(4-acetylphenoxy)butanoic...
-
containing the
enediyne functional group that
model the
activity of the
calicheamicin class of antibiotics.
Sarpong received his Ph.D. in 2001.
Sarpong moved...
