-
monophosphate (cyclic GMP-AMP,
cGAMP) is the
first cyclic di-nucleotide
found in metazoa. In
mammalian cells,
cGAMP is
synthesized by
cyclic GMP-AMP...
-
Synthase (cGAS)
triggers reaction of GTP and ATP to form
cyclic GMP-AMP (
cGAMP).
cGAMP binds to
Stimulator of
Interferon Genes (STING)
which triggers phosphorylation...
-
Cyclic GMP-AMP
synthase (cGAS,
cGAMP synthase),
belonging to the
nucleotidyltransferase family, is a
cytosolic DNA
sensor that
activates a type-I interferon...
-
known hydrolase of
cGAMP, the
natural ligand and
activator of STING. ENPP1 is an
extracellular enzyme,
which led her to
propose that
cGAMP is
exported for...
-
Phylogenetic tree of
Poxviridae and
distribution of
cGAMP nucleases across member species and genera...
-
cyclic guanosine monophosphate–adenosine
monophosphate (cyclic GMP-AMP, or
cGAMP).
After cyclic GMP-AMP
bound STING is activated, it
enhances TBK1's activity...
-
synthase (cGAS;
cGAMP synthase), and a new
second messenger,
Cyclic guanosine monophosphate–adenosine
monophosphate (cyclic GMP-AMP,
cGAMP),
which play key...
- Sciences, for work
including the
cytoplasmic DNA
sensor cGAS and its
product cGAMP, a
novel cyclic dinucleotide second messenger involved in
innate immune...
- SLC19A1 has also been
shown to
transport the
immune second messenger 2'3'-
cGAMP.
Individuals carrying a
specific polymorphism of SLC19A1 (c.80GG) have lower...
- Borrow, and J. Rehwinkel, "Viruses
transfer the
antival second messenger cGAMP between cells", Science, vol. 349,
issue 6253 (2015), pp. 1228–1232. L....
