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Cyclic ADP-ribose,
frequently abbreviated as
cADPR, is a
cyclic adenine nucleotide (like cAMP) with two
phosphate groups present on 5' OH of the adenosine...
- to
synthesize the calcium-releasing
second messengers cyclic ADP-ribose (
cADPR) and
nicotinic acid
adenine dinucleotide phosphate (NAADP). CD38 is most...
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enzyme poly ADP
ribose polymerase. ADPR is
created from
cyclic ADP-ribose (
cADPR) by the CD38
enzyme using nicotinamide adenine dinucleotide (NAD+) as a...
- "Biochemistry, biology, and
pharmacology of
cyclic adenosine diphosphoribose (
cADPR)". Curr. Med. Chem. 11 (7): 847–55. doi:10.2174/0929867043455602. PMID 15078169...
- the
chemical reaction NAD+ + H2O ⇌ {\displaystyle \rightleftharpoons }
cADPR + H2O +
nicotinamide ⇌ {\displaystyle \rightleftharpoons } ADP-ribose +...
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forms pyrophosphate esters, e.g.
tetraethyl pyrophosphate, ADP, dADP, ADPR,
cADPR, CDP, dCDP, GDP, dGDP, UDP, dTDP, MEcPP, HMBPP, DMAPP, IPP, GPP, FPP, GGPP...
- (
cADPR) from NAD+,
although CD157 is a much
weaker catalyst than CD38.
cADPR is
required for
regulation of Ca2+ in cells. Only CD38
hydrolyzed cADPR to...
- SARM1, the TIR
NADase activity leads to the
production of Nam, ADPR and
cADPR and the
activation of
downstream pathways involved in
Wallerian degeneration...
-
colleagues discovered not one but two Ca2+-mobilizing
second messengers,
cADPR and
NAADP from the
effects of
nucleotides on Ca2+
release in sea urchin...
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Second messengers IP3
NAADP cADPR Intracellular channels IP3
receptor Ryanodine receptor Calcium-induced
calcium release Intracellular pumps SERCA ATP2A1...
