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Cyclic ADP-ribose,
frequently abbreviated as
cADPR, is a
cyclic adenine nucleotide (like cAMP) with two
phosphate groups present on 5' OH of the adenosine...
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synthesize the calcium-releasing
second messengers cyclic ADP-ribose (
cADPR) and
nicotinic acid
adenine dinucleotide phosphate (NAADP). CD38 is most...
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enzyme poly ADP
ribose polymerase. ADPR is
created from
cyclic ADP-ribose (
cADPR) by the CD38
enzyme using nicotinamide adenine dinucleotide (NAD+) as a...
- the
chemical reaction NAD+ + H2O ⇌ {\displaystyle \rightleftharpoons }
cADPR + H2O +
nicotinamide ⇌ {\displaystyle \rightleftharpoons } ADP-ribose +...
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forms pyrophosphate esters, e.g.
tetraethyl pyrophosphate, ADP, dADP, ADPR,
cADPR, CDP, dCDP, GDP, dGDP, UDP, dTDP, MEcPP, HMBPP, DMAPP, IPP, GPP, FPP, GGPP...
- "Biochemistry, biology, and
pharmacology of
cyclic adenosine diphosphoribose (
cADPR)". Curr. Med. Chem. 11 (7): 847–55. doi:10.2174/0929867043455602. PMID 15078169...
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Second messengers IP3
NAADP cADPR Intracellular channels IP3
receptor Ryanodine receptor Calcium-induced
calcium release Intracellular pumps SERCA ATP2A1...
- or
extracellular NADase,
whereas type II CD38
contains an
intracellular cADPR. CD38
consumes NAD,
which can
produce second messengers that help regulate...
- WldS. SARM1
catalyzes the
synthesis and
hydrolysis of
cyclic ADP-ribose (
cADPR) from NAD+ to ADP-ribose. SARM1
activation locally triggers a
rapid collapse...
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Second messengers IP3
NAADP cADPR Intracellular channels IP3
receptor Ryanodine receptor Calcium-induced
calcium release Intracellular pumps SERCA ATP2A1...
