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Bryostatins are a
group of
macrolide lactones from (bacterial
symbionts of) the
marine organism Bugula neritina that were
first collected and provided...
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called bryostatins can be
extracted from the
marine bryozoan Bugula neritina. In 2001
pharmaceutical company GPC
Biotech licensed bryostatin 1 from Arizona...
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since been used in the
synthesis of
several products,
particularly the
bryostatins. Evans–Tishchenko
reaction Saksena, Anil; Mangiaracina,
Pietro (1983)...
- fish meal),
pharmaceuticals (e.g. fish oil,
krill oil,
cytarabine and
bryostatin) and
various industrial chemicals (e.g.
chitin and bioplastics, formerly...
- than was
previously achieved. For example,
total syntheses of roxaticin,
bryostatin and
cryptocaryol were
accomplished via
double Krische allylation of 1...
-
Endobugula sertula,
produces the
bryostatins, a
group of
around twenty bioactive natural products. The
bryostatins are
under investigation for their...
- myricitrin, gossypol.
Other PKCIs : Verbascoside, BIM-1, Ro31-8220.
Bryostatin 1 can act as a PKC inhibitor; It was
investigated for cancer. Tamoxifen...
- α-cyclodextrin; SFX-01, STP-2;
broccoli sprout extract) –
various actions Bryostatin-1 (MW-904) –
protein kinase C
stimulant CJRB-303 (CJRB-901, MRx-0006)...
-
discovery that
Bryostatin-1 can be used to
treat latent HIV
infection and
formed the
basis for
clinical trials on the use of
Bryostatin as a
latent infection-reversing...
- 1998). "Reversible
phosphorylation of Bcl2
following interleukin 3 or
bryostatin 1 is
mediated by
direct interaction with
protein phosphatase 2A". The...
