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Bryostatins are a
group of
macrolide lactones from (bacterial
symbionts of) the
marine organism Bugula neritina that were
first collected and provided...
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called bryostatins can be
extracted from the
marine bryozoan Bugula neritina. In 2001
pharmaceutical company GPC
Biotech licensed bryostatin 1 from Arizona...
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Endobugula sertula,
produces the
bryostatins, a
group of
around twenty bioactive natural products. The
bryostatins are
under investigation for their...
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Other naturally occurring PKCIs are
miyabenol C, myricitrin, gossypol.
Bryostatin 1 can act as a PKC inhibitor; It was
investigated for cancer. Darovasertib...
- than was
previously achieved. For example,
total syntheses of roxaticin,
bryostatin and
cryptocaryol were
accomplished via
double Krische allylation of 1...
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since been used in the
synthesis of
several products,
particularly the
bryostatins. Evans–Tishchenko
reaction Saksena, Anil; Mangiaracina,
Pietro (1983)...
-
Bugula neritina attracted interest as a
source of
cytotoxic chemicals,
bryostatins,
under clinical investigation as anti-cancer agents. It was
first collected...
- such as
agelastatin A, terpestacin, and
bryostatins. In addition, he has
designed and
synthesized a new
bryostatin analogue; in
collaboration with Genetech...
- cancer, anti-inflammatory use and pain. One
class of
these agents are
bryostatin-like compounds,
under investigation as anti-cancer therapy.[citation needed]...
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elucidation of
numerous marine natural products such as the
anticancer agent bryostatin, the
insecticidal and
antifungal jaspamide,
diazonamide A and B, and many...
