- single-p****
membrane protein also
known as single-spanning
protein or
bitopic protein is a
transmembrane protein that
spans the
lipid bilayer only once...
- Gram-negative bacteria, and
outer membranes of
mitochondria and chloroplasts.
Bitopic proteins are
transmembrane proteins that span
across the
membrane only...
-
DiBerto JF, Che T, Qu Q, et al. (January 2023). "Structure-based
design of
bitopic ligands for the μ-opioid receptor". Nature. 613 (7945): 767–774. Bibcode:2023Natur...
-
Edrophonium Huperzine A
Ladostigil Ungeremine Lactucopicrin Acotiamide Hybrid/
bitopic ligands Compounds which function as quasi-irreversible
inhibitors of cholinesterase...
-
structural and
functional information about more than 6000 single-p**** (
bitopic)
transmembrane proteins from Homo sapiens,
Arabidopsis thaliana, Dictyostelium...
- for M2 but only
partial agonist)
Berberine Iper-8-Naph (alias N-8-Iper,
bitopic/dualsteric agonist)
Methacholine PAI (photoswitchable agonist) AFDX-384...
- symptoms. The drug is
described as a dual
orthosteric and
allosteric (i.e.,
bitopic)
modulator of the
dopamine D2 and D3 receptors, as an
atypical allosteric...
-
receptor types.
Heterobivalent ligands target two
different receptor types.
Bitopic ligands target an
orthosteric binding sites and
allosteric binding sites...
- 4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a
bitopic ligand that acts as a
negative allosteric modulator of the
dopamine D2...
- PMC 6016636. PMID 28419415.
Hovah ME,
Holzgrabe U (May 2024). "Bivalent and
bitopic ligands of the
opioid receptors: The
prospects of a dual approach". Med...
