- N-acetylserotonin.
Based on this mechanism, it
might be
expected that a
bisubstrate analog inhibitor,
derived from the
tethering of
indole and
CoASH parts...
- RE; Pulkoski-Gross, M; Liu, DR; Seeliger, MA (2012). "Highly specific,
bisubstrate-competitive Src
inhibitors from DNA-templated macrocycles".
Nature Chemical...
-
Fenna RE (August 1996). "2.3 A
resolution X-ray
crystal structure of the
bisubstrate analogue inhibitor salicylhydroxamic acid
bound to
human myeloperoxidase:...
- N1-acetyltransferase (hSSAT) 2jev:
CRYSTAL STRUCTURE OF
HUMAN SPERMINE,SPERMIDINE
ACETYLTRANSFERASE IN
COMPLEX WITH A
BISUBSTRATE ANALOG (N1-ACETYLSPERMINE-S-COA)....
-
catalytic center of
ATCase was
first made
possible by the
binding of a
bisubstrate analogue, N-(phosphonoacetyl)-L-aspartate (PALA). This
compound is a...
- 4MQ4; Bart AG,
Scott EE.
Crystal Structure of
hPNMT in
Complex with
bisubstrate inhibitor N-(3-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3...
- "Catechol-O-methyltransferase in
complex with
substituted 3'-deoxyribose
bisubstrate inhibitors". Acta Crystallographica.
Section D,
Biological Crystallography...
- 1gag:
CRYSTAL STRUCTURE OF THE
INSULIN RECEPTOR KINASE IN
COMPLEX WITH A
BISUBSTRATE INHIBITOR 1i44:
CRYSTALLOGRAPHIC STUDIES OF AN
ACTIVATION LOOP MUTANT...
-
enzymology with
previously utilized inhibition motifs. For example, a "
bisubstrate analog"
inhibits kinase action by
binding both the
conserved ATP binding...
- Ward SG (April 2010). "Toward the
development of
potent and
selective bisubstrate inhibitors of
protein arginine methyltransferases".
Bioorganic & Medicinal...
