-
toxicity are also modified. Non-classical
bioisosteres may
differ in a
multitude of ways from
classical bioisosteres, but
retain the
focus on
providing similar...
-
Chemistry of Drug
Design and Drug Action,
Second Edition, 2004
Nathan Brown.
Bioisosteres in
Medicinal Chemistry. Wiley-VCH, 2012, p. 237. ISBN 978-3-527-33015-7...
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FIGURE 7 |
Benzofuran bioisosteres of tryptamines.
Tomaszewski Z,
Johnson MP,
Huang X,
Nichols DE (May 1992). "Benzofuran
bioisosteres of
hallucinogenic tryptamines"...
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biochemistry and
medicinal chemistry,
phosphonate groups are used as
stable bioisosteres for phosphate, such as in the
antiviral nucleotide analog, Tenofovir...
- MacMillan,
David W. C. (June 2023). "General
access to
cubanes as
benzene bioisosteres". Nature. 618 (7965): 513–518. doi:10.1038/s41586-023-06021-8. ISSN 1476-4687...
-
Acylsulfonamides are of
particular interest due to
their ability to act as
bioisosteres of
carboxylic acids,
offering similar hydrogen bonding capabilities and...
-
Caignard DH,
Rivara S, Rodríguez-Franco MI (June 2015). "Novel N-Acetyl
Bioisosteres of Melatonin:
Melatonergic Receptor Pharmacology,
Physicochemical Studies...
-
Meanwell NA (March 2011). "Synopsis of Some
Recent Tactical Application of
Bioisosteres in Drug Design".
Journal of
Medicinal Chemistry. 54 (8): 2529–91. doi:10...
- (8): 3147–3176. doi:10.1021/cr950066q. PMID 11848856.
Brown N (2012).
Bioisosteres in
Medicinal Chemistry. Weinheim: Wiley-VCH. ISBN 978-3-527-33015-7....
- a
tetrazole which is
being used in
place of the
carboxylic acid as a
bioisostere.
Losartan is used for hypertension,
including in
people with left ventricular...
