- In
medicinal chemistry,
bioisosteres are
chemical substituents or
groups with
similar physical or
chemical properties which produce broadly similar biological...
-
compounds containing an
isostere is
called a
bioisostere. This is
frequently used in drug design: the
bioisostere will
still be
recognized and
accepted by...
- 1]propellane. The bicyclo[1.1.1]pentane
structure has been used as an
unusual bioisostere for a
phenyl ring.
Housane Staffane Wiberg,
Kenneth B.; Walker, Frederick...
- the
Dimroth rearrangement. 1,2,3-Triazole
finds use in
research as a
bioisostere for
imidazoles and
various carboxylic acid
derivatives in
medicinal chemistry...
- a
tetrazole which is
being used in
place of the
carboxylic acid as a
bioisostere.
Losartan is used for hypertension,
including in
people with left ventricular...
- [citation needed] A**** -
Crystallographic refinement and analysis.
BROOD -
Bioisostere identification using shape,
chemistry and
electrostatic similarity. EON...
- in
place of one
hydrogen atom at the C9α position.
Fluorine is a good
bioisostere for
hydrogen because it is
similar in size, with the
major difference...
- same
degree as in
synthetic areas.)
Chemistry portal Science portal Bioisostere Biological machines Chemoproteomics Drug
design Pharmacognosy Pharmacokinetics...
-
Pyrrolidinylmethylindoles (e.g., MPMI, 4-HO-MPMI (lucigenol), 5-MeO-MPMI)
Bioisosteres Benzofurans (e.g., 5-MeO-DiBF,
dimemebfe (5-MeO-BFE), mebfap) Benzothiophenes...
-
Pyrrolidinylmethylindoles (e.g., MPMI, 4-HO-MPMI (lucigenol), 5-MeO-MPMI)
Bioisosteres Benzofurans (e.g., 5-MeO-DiBF,
dimemebfe (5-MeO-BFE), mebfap) Benzothiophenes...
