-
especially in
hepatic cells, to
bioactivate the
prodrugs intracellularly to
active drugs. Type II
prodrugs are
bioactivated extracellularly,
either in the...
-
protoxins into
actual toxins. An
enzyme may be
reversibly or
irreversibly bioactivated. A
major mechanism of
irreversible bioactivation is
where a
piece of...
- or by
facilitated excretion from the body. Also, many
substances are
bioactivated by CYP3A4 to form
their active compounds, and many
protoxins are toxicated...
- Activation-dependent
agents are
relatively inert in
their original form, but are
bioactivated in the body into
metabolites or
intermediaries capable of
damaging human...
- and does not need to be
deacetylated at the 6-position in
order to be
bioactivated; this
makes 6-MAM
somewhat more
potent than heroin. 6-MAM is
rarely encountered...
-
Yoshigae Y, et al. (April 2010). "Human
carboxymethylenebutenolidase as a
bioactivating hydrolase of
olmesartan medoxomil in
liver and intestine". The Journal...
- Activation-dependent
agents are
relatively inert in
their original form, but are
bioactivated in the body into
metabolites or
intermediaries capable of
damaging human...
- drugs, such as penicillin, will bind
avidly to proteins.
Others must be
bioactivated into a
toxic compound that will in turn bind to proteins. The second...
- targeting/cell
labeling agents (tumor-specific agents)
Responsive (smart or
bioactivated)
agents pH-sensitive
agents Gadolinium(III)
containing MRI
contrast agents...
- are
often of
benefit to the body,
certain carcinogens and
toxins are
bioactivated by CYP2E1,
implicating the
enzyme in the
onset of
hepatotoxicity caused...
