-
Beclin-1 is a
protein that in
humans is
encoded by the BECN1 gene.
Beclin-1 is a
mammalian ortholog of the
yeast autophagy-related gene 6 (Atg6) and...
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phosphorylates and
activates Beclin-1 (mammalian
homologue of Atg6),
which is also part of a
protein complex. The autophagy-inducible
Beclin-1
complex contains...
- Hess, Jaqueline; Yardeni, Gil; de La Harpe, Marylaure; Priemer, Clara;
Beclin, Francesca; Saadain, Sarah; Cauz-Santos, Luiz A; Temsch, Eva M; Weiss-Schneeweiss...
-
Rubicon (run
domain Beclin-1-interacting and cysteine-rich domain-containing protein) is a
protein that in
humans is
encoded by the
RUBCN gene. Rubicon...
- lysosomes. TRIM16
gathers ULK1 and prin****l
components (
Beclin 1 and ATG16L1) of
other complexes (
Beclin 1-VPS34-ATG14 and ATG16L1-ATG5-ATG12)
initiating autophagy...
- elucidated.
Models have
proposed that the
active ULK1
directly phosphorylates Beclin-1 at Ser 14 and
activates the pro-autophagy
class III
phosphoinositide 3-kinase...
- Hess, Jaqueline; Yardeni, Gil; de La Harpe, Marylaure; Priemer, Clara;
Beclin, Francesca; Saadain, Sarah; Cauz-Santos, Luiz A; Temsch, Eva M; Weiss-Schneeweiss...
- mouse, and human.
Levine discovered the
first mammalian autophagy gene,
Beclin 1, and
later went on to
directly ****ociate this gene with the
protein Bcl-2...
- (November 1998). "Protection
against fatal Sindbis virus encephalitis by
beclin, a
novel Bcl-2-interacting protein".
Journal of Virology. 72 (11): 8586–8596...
-
identification of
novel autophagy regulators, such as the
components in
Beclin 1-hVPS34
complex (class 3 PI3K), Atg14L, Rubicon, and NRBF2,
which play...
