-
Baccatin III is an
isolate from the yew tree (Genera Taxus).
Baccatin III is a
precursor to the anti-cancer drug pa****axel (Taxol). In 2014, researchers...
- 10-O-acetyltransferase
converts 10-deacetylbaccatin to
baccatin III: acetyl-CoA + 10-deacetylbaccatin III ⇌ CoA +
baccatin III CID 6712096 from
PubChem - 7-Epi-10-Deacetylbaccatin...
-
pancreas as well. Taxanes,
including pa****axel, 10-deacetylbaccatin III,
baccatin III, pa****axel C, and 7-epipa****axel, have been
found in the
leaves and...
- potential. The pa****axel
molecule consists of a
tetracyclic core
called baccatin III and an
amide tail. The core
rings are
conveniently called (from left...
-
Richard C. A.; Bornmann,
William G. (1996-01-01). "Total
Synthesis of
Baccatin III and Taxol".
Journal of the
American Chemical Society. 118 (12): 2843–2859...
-
hydroxylation reactions, and a few others, are
needed to
convert taxadiene to
baccatin III. Enzymatically,
taxadiene is
produced from
geranylgeranyl pyrophosphate...
- doi:10.1021/ja01084a034. Danishefsky; et al. (1996). "Total
Synthesis of
Baccatin III and Taxol".
Journal of the
American Chemical Society. 118 (12): 2843–2859...
- Alaimo, C. A.; Coburn, C. A.; Di Grandi, M. J. (1996). "Total
Synthesis of
Baccatin III and Taxol".
Journal of the
American Chemical Society. 118 (12): 2843–2859...
- (the
final product is
baccatin III
which lacks the
amide tail
found in
taxol itself) and that it is
racemic (the
product baccatin III is
optically inactive)...
-
Baccatin III (left) Pa****axel (right)...
