-
species shows that only
BaDHFR has the
combination phenylalanine and
tyrosine in
positions 96 and 102, respectively.
BaDHFR's resistance to trimethoprim...
- methotrexate. The HSR was
found to due to the
amplification of the
DHFR gene.
Biedler JL;
Spengler BA (1976-01-16). "Metaphase
chromosome anomaly: ****ociation with...
-
methotrexate and pemetrexed.
Methotrexate inhibits dihydrofolate reductase (
DHFR), an
enzyme that
regenerates tetrahydrofolate from dihydrofolate. When the...
-
target due to
mutations in
corresponding genes (like, at the
cytosol level,
dhfr and dhps in sulfadoxine-pyrimethamine
resistance or, at the mitochondrion...
- methotrexate) had
increased levels of the
dihydrofolate reductase enzyme (
DHFR), a key
component of DNA synthesis.
Using her
skills in cytogenetics, Biedler...
-
determination of the
enzyme dihydrofolate reductase-thymidylate
synthase (
DHFR-TS) from
Cryptosporidium hominis, an
important advancement in Cryptosporidium...
- (2): 303–308. PMC 2476383. PMID 4864652.
Keystone JS,
Kozarsky PE,
Connor BA,
Nothdurft HD,
Mendelson M,
Leder K (2018).
Travel Medicine E-Book. Elsevier...
- ONE, 2009. 4(2): p. e4569. Raman, J., et al., Five
years of large-scale
dhfr and dhps
mutation surveillance following the
phased implementation of artesunate...
-
dihydrofolate reductase (
DHFR) gene. However,
methotrexate therapy appears to
select for
cells with
extra copies (amplification) of
DHFR,
which are resistant...
