- An
autophagosome is a
spherical structure with
double layer membranes. It is the key
structure in macroautophagy, the
intracellular degradation system...
- from the rest of the cell
within a double-membrane
vesicle known as an
autophagosome, which, in time,
fuses with an
available lysosome,
bringing its specialty...
- in
autophagy substrate selection and
autophagosome biogenesis. LC3 is the most
widely used
marker of
autophagosomes. LC3 was
originally identified as a...
- (PAMPs or DAMPs), the
removal of
senescent cells is non-inflammatory.
Autophagosomes are
different from
phagosomes in that they are
mainly used to selectively...
- phagop**** and
eventually become the
contents of the
fully ****embled
autophagosome.
Autophagosome biogenesis requires the
initiation and
growth of phagop****s...
- (ATG8)
lipidation and
autophagosome formation. This
complex localizes to the
membrane and is
released just
before or
after autophagosome completion. Furthermore...
-
section of the cytoplasm,
generating the
autophagosome, a
distinctive double-membraned organelle. The
autophagosome then
joins the
lysosome to
create an autolysosome...
- SQSTM1 gene. Also
known as the ubiquitin-binding
protein p62, it is an
autophagosome cargo protein that
targets other proteins that bind to it for selective...
- and will bind to BCL2 in the
outer membrane. This
relocation enables autophagosome nucleation. AMBRA1
protein is
involved in
several cellular processes...
-
signal transduction amplifiers. Recently, σ1R has been
implicated in
autophagosome formation and maturation.
Autophagy is a
broad homeostatic, metabolic...
