-
consisting of a catalytic, substrate-binding
domain and an
autoinhibitory domain. For the
autoinhibitory domain to
become functional, it must
cause the protein...
-
homology (PH) domain,
which reduces the
kinase activity of
ROCKs by an
autoinhibitory intramolecular fold if RhoA-GTP is not present. Rat
ROCKs were discovered...
-
intracellular signaling molecule generated by IP6K1,
which relieves an
autoinhibitory domain of PI3K p85α to
drive endocytosis and degradation. The Na+/K+-ATPase...
-
delta genes. All of the
isoforms of
CaMKII have: a
catalytic domain, an
autoinhibitory domain, a
variable segment, and a self-****ociation domain. The catalytic...
-
downstream pathways. When GAD is not
bound to CaM, the
CaMBD acts as an
autoinhibitory domain, thus
deactivating GAD in the
absence of stress. Interesting...
- off calcium-dependent
inactivation in L-type
calcium channels by an
autoinhibitory domain".
Proceedings of the
National Academy of
Sciences of the United...
-
complex and
subsequent fusion. The Habc domain, however,
serves as an
autoinhibitory domain in syntaxin. It has been
shown to fold over and ****ociate with...
- c-Raf) in the CR2
hinge region.
During B-Raf activation, the protein's
autoinhibitory CR1
domain first binds Ras-GTP's
effector domain to the CR1 Ras-binding...
-
region region 147 247 SH2
region 152 154 Beta-strand
region site 158 158
autoinhibitory site [polypeptide binding] site 158 158
phosphotyrosine binding pocket...
-
special case of
protein enzyme inhibitors are
zymogens that
contain an
autoinhibitory N-terminal
peptide that
binds to the
active site of
enzyme that intramolecularly...
