-
Fentanyl is a
synthetic piperidine opioid structurally similar to
arylpiperidines. It is a
strong μ-receptor
agonist that is 80–100
times more potent...
- (November 2012). "Systematic in vivo
screening of a
series of 1-propyl-4-
arylpiperidines against dopaminergic and
serotonergic properties in rat brain: a scaffold-jumping...
- 1970). "4-substituted piperidines. V.
Local anesthetic 4-aminoalkoxy-4-
arylpiperidines".
Journal of
Medicinal Chemistry. 13 (5): 835–8. doi:10.1021/jm00299a009...
- & DAT = 13.8nM. This is not the
first time that
Sanofi produced a 3-
arylpiperidine having BAT
dopaminergic properties. For example,...
- Capuano, Ben; Crosby, Ian T. (2012). "Synthesis and SAR
study of 4-
arylpiperidines and 4-aryl-1,2,3,6-tetrahydropyridines as 5-HT2C agonists". Bioorganic...
- pentazocine.
Ketobemidone US 4081450,
Zimmerman DM, "1,3,4-Trisubstituted-4-
arylpiperidines and
their preparation",
issued 28
April 1978, ****igned to Eli Lilly...
- "Alkoxylamino and
alkoxycarbonylamino derivatives of 1(aroylalkyl)-4-
arylpiperidines.",
published 1961
Ridley RM,
Haystead TA,
Baker HF, Crow TJ (June...
