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Arrestins (abbreviated Arr) are a
small family of
proteins important for
regulating signal transduction at G protein-coupled receptors.
Arrestins were...
-
Arrestin, beta 1, also
known as ARRB1, is a
protein which in
humans is
encoded by the ARRB1 gene.
Members of
arrestin/beta-
arrestin protein family are...
- The
arrestin family of
proteins is
subdivided into α-
arrestins (also
referred to as
arrestin-related
trafficking adaptors (ARTs) or
arrestin-like yeast...
- Beta-
arrestin-2, or β-arrestin2, also
known as
arrestin beta-2, is an
intracellular protein that in
humans is
encoded by the ARRB2 gene.
Members of...
- phosphorylation, the GPCR's
affinity for β-
arrestin (β-
arrestin-1/2 in most tissues) is increased, at
which point β-
arrestin may bind and act to both sterically...
-
inhibitory protein,
arrestin, then
binds to the
phosphorylated rhodopsins to
further inhibit the
rhodopsin activity.
While arrestin shuts off rhodopsin...
-
potent than both
mitragynine and morphine. 7-OH does not
activate the β-
arrestin pathway like
traditional opioids,
meaning symptoms such as respiratory...
- activation.
Arrestin binding to phosphorylated,
active receptor also
enables receptor signaling through arrestin partner proteins. Thus the GRK/
arrestin system...
-
phosphorylates the
Metarhodopsin II,
reducing its
binding affinity for transducin.
Arrestin then
completely deactivates the phosphorylated-metarhodopsin II, terminating...
- receptor,
selective for
activation of the G-protein
signalling pathway over β-
arrestin 2 recruitment. In
animal studies it
produces analgesic effects but with...
