-
potential therapeutic use of
PIKfyve inhibitors awaits clinical trials.
PIKfyve physically ****ociates with its
regulator ArPIKfyve, a
protein encoded by the...
-
Protein VAC14 homolog, also
known as
ArPIKfyve (****ociated
Regulator of
PIKfyve), is a
protein that in
humans is
encoded by the VAC14 gene. The content...
-
PIKfyve,
called ArPIKfyve/VAC14, that
scaffolds a
ternary regulatory complex,
known as the PAS
complex (from the
first letters of
PIKfyve/
ArPIKfyve/Sac3)...
- hetero-oligomer with
ArPIKfyve (gene symbol, VAC14) and this
binary complex ****ociates with the
phosphoinositide kinase PIKFYVE in a
ternary PAS complex...
- is
synthesized from PtdIns3P by the
PIKfyve complex that
includes ArPIKfyve and Sac3/Fig4. Noteworthy, the
PIKfyve complex underlies both PtdIns(3,5)P2...
-
progression of
endosomal transport.
Novel Sac
phosphatase joins the
ArPIKfyve-
PIKfyve complex". The
Journal of
Biological Chemistry. 282 (33): 23878–91...
- Jason;
Soans Aleric;
Finley Russell L;
Shisheva ****ia (Dec 2003). "Active
PIKfyve ****ociates with and
promotes the
membrane attachment of the late endosome-to-trans-Golgi...
- Stow JL,
Teasdale RD (April 2010). "Inhibition of the PtdIns(5)
kinase PIKfyve disrupts intracellular replication of Salmonella". The EMBO Journal. 29...
- FOXO3a, CDKN1B/p27kip,
cyclin D2, NIPA, RAC1, CDC42, p130CAS, SHP1, and
PIKFYVE.
Phosphorylated ALK
activates multiple downstream signal transduction pathways...
-
perceptive deafness; 217400; SLC4A11
Corneal fleck dystrophy; 121850;
PIKFYVE Cornelia de
Lange syndrome 1; 122470;
NIPBL Cornelia de
Lange syndrome...
