- In
biochemistry and
molecular genetics, an AP site (
apurinic/apyrimidinic site), also
known as an
abasic site, is a
location in DNA (also in RNA but much...
- The
enzyme DNA-(
apurinic or
apyrimidinic site) lyase, also
referred to as DNA-(
apurinic or
apyrimidinic site) 5'-phosphomonoester-lyase (systematic name)...
- GC tautomers.
Depurination – Loss of a
purine base (A or G) to form an
apurinic site (AP site).
Deamination –
Hydrolysis changes a
normal base to an atypical...
- rate. When
depurination occurs with DNA, it
leads to the
formation of
apurinic site and
results in an
alteration of the structure.
Studies estimate that...
-
phosphodiester backbone of DNA,
followed by
inaccurate repair or
replication of the
apurinic site
leading to
mutation and
eventually cancer. This
genotoxic mechanism...
- activation-induced (cytidine)
deaminase (AID),
uracil DNA glycosylase, and apyrimidic/
apurinic (AP)-endonucleases. AID
begins the
process of
class switching by deaminating...
-
oxygen species increase leading to the ac****ulation of DNA
damages such as
apurinic/apyrimidinic
sites and double-strand breaks. Also in non-replicating cells...
- DNA-(
apurinic or
apyrimidinic site)
lyase is an
enzyme that in
humans is
encoded by the APEX1 gene.
Apurinic/apyrimidinic (AP)
sites (also
called "abasic...
-
Apurinic/apyrimidinic (AP)
endonuclease is an
enzyme that is
involved in the DNA base
excision repair pathway (BER). Its main role in the
repair of damaged...
- enzyme, uracil-DNA glycosylase,
followed by
cleavage of the DNA
backbone by
apurinic endonuclease. Error-prone DNA
polymerases are then
recruited to fill in...
