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Aptamers are
oligomers of
artificial ssDNA, RNA, XNA, or
peptide that bind a
specific target molecule, or
family of
target molecules. They
exhibit a range...
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Aptamers, single-stranded RNA and DNA sequences, bind to an
analyte and
change their conformation. They
function as
nucleic acids selectively binding molecules...
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synthetically derived RNA
aptamer born out of the need for a way of
studying the role of RNAs at the
cellular level. This
aptamer was
created using Systematic...
- Anti-thrombin
aptamers are G-quadruplex-bearing oligonucleotides,
which recognizes the
exosites of
human thrombin. The
first anti-thrombin
aptamer, TBA, was...
- ligands.
These single-stranded DNA or RNA are
commonly referred to as
aptamers.
Although SELEX has
emerged as the most
commonly used name for the procedure...
- An L-ribonucleic acid
aptamer (L-RNA
aptamer,
trade name Spiegelmer) is an RNA-like
molecule built from L-ribose units. It is an
artificial oligonucleotide...
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antisense RNA (asRNA), RNA
interference (RNAi), RNA
activation (RNAa) and RNA
aptamers. Of the four types, mRNA-based
therapy is the only type
which is based...
- immuno-RCA, the
ssDNA RCA
primer can be
conjugated to the 3' end of a DNA
aptamer as well. The
primer tail can be
amplified through rolling circle amplification...
- pair to DNA
aptamer generation by in
vitro selection (SELEX) and
demonstrated the
genetic alphabet expansion significantly augment DNA
aptamer affinities...
-
Known examples of
smart ligands include DNA
smart aptamers; however, RNA and
peptide smart aptamers can also be developed.
Smart ligands can find a set...
