- The
apoptosome is a
large quaternary protein structure formed in the
process of apoptosis. Its
formation is
triggered by the
release of
cytochrome c from...
-
binding cytochrome c and dATP, this
protein forms an
oligomeric apoptosome. The
apoptosome binds and
cleaves Procaspase-9 protein,
releasing its mature,...
- the
release of
cytochrome c from
mitochondria and
activation of apaf-1 (
apoptosome),
which then
cleaves the pro-enzyme of caspase-9 into the
active dimer...
- bind to pro-caspase-9 to
create a
protein complex known as an
apoptosome. The
apoptosome cleaves the pro-caspase to its
active form of caspase-9, which...
- death-inducing
signaling complex (DISC)
during extrinsic apoptosis The
apoptosome during intrinsic apoptosis The
inflammasome during pyroptosis Once appropriately...
- NR4A1, Noxa, PPP2CA, PSEN1, RAD9A, RRAS, RTN4, SMN1, SOD1, and TP53BP2.
Apoptosome Bcl-2
homologous antagonist killer (BAK) Bcl-2-****ociated X
protein (BAX)...
-
cytochrome c (which is one of the
parts needed to
activate caspase-9 via the
apoptosome), Smac/Diablo and Omi/HtrA2 (which
suppress the
inhibitor of apoptosis...
-
release of
cytochrome c,
which then
recruits Apaf-1 and dATP/ATP into an
apoptosome complex. This
complex then
cleaves procaspase-9,
activating caspase-9...
-
Cytochrome c
promotes the
activation of caspase-9
through the
formation of the
apoptosome. Once caspase-9 is activated, it can
cleave and
activate caspase-3 resulting...
-
apoptosis by
releasing cytochrome c,
which directly induces the
formation of
apoptosomes. Additionally, they are a
source of
various damage-****ociated molecular...
