- In pharmacology, an
antitarget (or off-target) is a receptor, enzyme, or
other biological target that, when
affected by a drug,
causes undesirable side-effects...
-
called torsades de pointes). This has made hERG
inhibition an
important antitarget that must be
avoided during drug development. hERG has also been ****ociated...
-
memory in aged monkeys).
Activation of the 5-HT2B
receptor is a well-known
antitarget and is ****ociated with
cardiac valvulopathy. However, not all 5-HT2B receptor...
- (hERG) that can lead to
heart problems (potent
inhibition of the hERG
antitarget and
predicted cardiotoxicity).
Adrafinil (Olmifon, CRL-40028, N-hydroxymodafinil)...
- 2165/00003088-198510030-00002. PMID 2861928. S2CID 21305772. Vaz RJ,
Klabunde T (2008).
Antitargets:
Prediction and
Prevention of Drug Side Effects. John
Wiley & Sons. pp...
-
affect any
other important "off-target"
molecules (often
referred to as
antitargets)
since drug
interactions with off-target
molecules may lead to undesirable...
-
sigma σ1
receptor (Ki = 41.6 nM). The drug has high
affinity for the hERG
antitarget (IC50Tooltip half-maximal
inhibitory concentration = 130 nM) and could...
-
Proarrhythmic Effects Thereof". In
Urban L,
Patel V, Vaz RJ (eds.).
Antitargets and Drug Safety. Wiley. pp. 303–. ISBN 978-3-527-67367-4.
Archer SL,...
-
candidate based on its safety,
specificity of effect, and
efficacy of doses.
Antitarget Bioinformatics Biomedical informatics Cheminformatics Drug
discovery hit...
-
suitable for use in
humans because of
excessive inhibition of the hERG
antitarget. PNU-282987 has been
shown to
initiate signaling that
leads to
adult neurogeneis...
