-
Antifolates are a
class of
antimetabolite medications that
antagonise (that is, block) the
actions of
folic acid (vitamin B9).
Folic acid's
primary function...
-
children with ALL.
Remissions were brief, but the
principle was
clear —
antifolates could suppress proliferation of
malignant cells, and
could thereby re-establish...
-
Salvage pathways are
targets for drug development, one
family being called antifolates. A
number of
other biologically-important substances, like methionine...
-
inhibitors such as rifampin, act upon DNA-dependent RNA polymerase.
Antifolates act
primarily as
inhibitors of both RNA and DNA, and are
often grouped...
- in
structure to the
metabolite that they
interfere with, such as the
antifolates that
interfere with the use of
folic acid; thus,
competitive inhibition...
- and
antifolate pharmacology".
Seminars in Oncology. 24 (5
Suppl 18): S18-30-S18-39. PMID 9420019.
Gonen N, ****araf YG (August 2012). "
Antifolates in cancer...
-
appear to be
extremely rare.
Trachtman JN,
Pagano V (December 2015). "
Antifolates and MTHFR".
Therapeutic Drug Monitoring. 37 (6): 697–698. doi:10.1097/FTD...
- uses
active site
mutants in
BaDHFR to
guide lead
optimization for new
antifolate inhibitors. DHFR has been used as a tool to
detect protein–protein interactions...
-
along with a
delay in
mental and
physical development.
Valproate has
antifolate effects,
leading to
neural tube closure-related
defects such as spina...
-
Hemozoin inhibitors Antifolates Sesquiterpene lactones artemether#
artemisinin artemotil artesunate#
dihydroartemisinin Other atovaquone (+ proguanil)...
