-
Antifolates are a
class of
antimetabolite medications that
antagonise (that is, block) the
actions of
folic acid (vitamin B9).
Folic acid's
primary function...
- uses
active site
mutants in
BaDHFR to
guide lead
optimization for new
antifolate inhibitors. DHFR has been used as a tool to
detect protein–protein interactions...
- ISBN 0-7167-4339-6. Kwon YK,
Higgins MB,
Rabinowitz JD (August 2010). "
Antifolate-induced
depletion of
intracellular glycine and
purines inhibits thymineless...
-
disease flares in some people.
Methotrexate is an
antimetabolite of the
antifolate type. It is
thought to
affect cancer and
rheumatoid arthritis by two different...
-
along with a
delay in
mental and
physical development.
Valproate has
antifolate effects,
leading to
neural tube closure-related
defects such as spina...
- May 22, 1948, one of the CCRF's
first patients to
respond to Farber's
antifolate, a twelve-year-old boy
named Einar Gustafson,
appeared on the show. Despite...
-
appear to be
extremely rare.
Trachtman JN,
Pagano V (December 2015). "
Antifolates and MTHFR".
Therapeutic Drug Monitoring. 37 (6): 697–698. doi:10.1097/FTD...
-
Phototrexate is a
photochromic antifolate drug
developed at the
Institute for
Bioengineering of
Catalonia (IBEC, The
Barcelona Institute of
Science and...
- most
common cancer in children,
using aminopterin. This, and
another antifolate drug,
methotrexate used by Dr. Farber, were
discovered and
supplied by...
- and
antifolate pharmacology".
Seminars in Oncology. 24 (5
Suppl 18): S18-30-S18-39. PMID 9420019.
Gonen N, ****araf YG (August 2012). "
Antifolates in cancer...
