-
Antifolates are a
class of
antimetabolite medications that
antagonise (that is, block) the
actions of
folic acid (vitamin B9).
Folic acid's
primary function...
- uses
active site
mutants in
BaDHFR to
guide lead
optimization for new
antifolate inhibitors. DHFR has been used as a tool to
detect protein–protein interactions...
- and
antifolate pharmacology".
Seminars in Oncology. 24 (5
Suppl 18): S18-30-S18-39. PMID 9420019.
Gonen N, ****araf YG (August 2012). "
Antifolates in cancer...
-
children with ALL.
Remissions were brief, but the
principle was
clear —
antifolates could suppress proliferation of
malignant cells, and
could thereby re-establish...
- that
inhibits the
function of
dihydrofolate reductase, and is a type of
antifolate.
Since folate is
needed by
rapidly dividing cells to make thymine, this...
- and
anemia can also occur.
Other antifolate agents such as
methotrexate and
trimethoprim may
potentiate the
antifolate actions of pyrimethamine, leading...
- Immunoglobulin,
modulates the
immune system. IV N/A
Varies Methotrexate Antifolate;
inhibits dihydrofolate reductase. PO, IV, IM, SC, IT D (Au) Myeosuppression...
- in
structure to the
metabolite that they
interfere with, such as the
antifolates that
interfere with the use of
folic acid; thus,
competitive inhibition...
-
appear to be
extremely rare.
Trachtman JN,
Pagano V (December 2015). "
Antifolates and MTHFR".
Therapeutic Drug Monitoring. 37 (6): 697–698. doi:10.1097/FTD...
- ISBN 0-7167-4339-6. Kwon YK,
Higgins MB,
Rabinowitz JD (August 2010). "
Antifolate-induced
depletion of
intracellular glycine and
purines inhibits thymineless...
