Definition of Antifolate. Meaning of Antifolate. Synonyms of Antifolate

- Antifolates are a class of antimetabolite medications that antagonise (that is, block) the actions of folic acid (vitamin B9). Folic acid's primary function...
- uses active site mutants in BaDHFR to guide lead optimization for new antifolate inhibitors. DHFR has been used as a tool to detect protein–protein interactions...
- and antifolate pharmacology". Seminars in Oncology. 24 (5 Suppl 18): S18-30-S18-39. PMID 9420019. Gonen N, ****araf YG (August 2012). "Antifolates in cancer...
- Phototrexate is a photochromic antifolate drug developed at the Institute for Bioengineering of Catalonia (IBEC, The Barcelona Institute of Science and...
- and anemia can also occur. Other antifolate agents such as methotrexate and trimethoprim may potentiate the antifolate actions of pyrimethamine, leading...
- along with a delay in mental and physical development. Valproate has antifolate effects, leading to neural tube closure-related defects such as spina...
- disease flares in some people. Methotrexate is an antimetabolite of the antifolate type. It is thought to affect cancer and rheumatoid arthritis by two different...
- ISBN 0-7167-4339-6. Kwon YK, Higgins MB, Rabinowitz JD (August 2010). "Antifolate-induced depletion of intracellular glycine and purines inhibits thymineless...
- They are treated after the first trimester because pyrimethamine has an antifolate effect, and lack of folic acid can interfere with fetal brain formation...
- appear to be extremely rare. Trachtman JN, Pagano V (December 2015). "Antifolates and MTHFR". Therapeutic Drug Monitoring. 37 (6): 697–698. doi:10.1097/FTD...