-
families of
proteins act as
negative regulators categorized into
either antiapoptotic factors, such as IAPs and Bcl-2
proteins or
prosurvival factors like...
-
electrostatic potential of the
binding groove,
suggest differences in
antiapoptotic activity for the two isoforms. BCL-2 is
localized to the
outer membrane...
-
through damaging the ubiquitin-protease system. It also acts as an
antiapoptotic agent preventing programmed cell
death and
controls the
production of...
- post-translational modifications.
After activation, PUMA
interacts with
antiapoptotic Bcl-2
family members, thus
freeing Bax and/or Bak
which are then able...
-
interacts with caspases,
while the RING
finger domain sometimes enhances antiapoptotic activity but does not
inhibit apoptosis alone. Two
transcript variants...
- RB; Hay, N (2006). "Mitochondrial hexokinases,
novel mediators of the
antiapoptotic effects of
growth factors and Akt". Oncogene. 25 (34): 4683–96. doi:10...
-
These include regulating gene expression, anti-inflammatory effects,
antiapoptotic effects and
protecting endothelial barrier function.: 3162 Treatment...
- (BCL2-related)".
Kelly GL, Str****er A (March 2020). "Toward
Targeting Antiapoptotic MCL-1 for
Cancer Therapy".
Annual Review of
Cancer Biology. 4: 299–313...
-
apoptosis by
docosahexaenoic acid (22:6n-3): Role of
phosphatidylserine in
antiapoptotic effect".
Journal of
Biological Chemistry. 275 (45): 35215–35223. doi:10...
- commercialization. The
substance acts as a pan-caspase
inhibitor and has
antiapoptotic and
antiinflammatory effects. It was
developed for the
treatment of...
