-
Amylin, or
islet amyloid polypeptide (IAPP), is a 37-residue
peptide hormone. It is co-secreted with
insulin from the
pancreatic β-cells in the
ratio of...
- The
amylin receptors (AMYRs) are
heterodimers of the
calcitonin receptor that are
bound to by
amylin with high
affinity and
consist of AMY1, AMY2, and...
- Dual
amylin and
calcitonin receptor agonists (DACRAs) are a
class of
drugs that act as
agonists at the
amylin receptor and
calcitonin receptor that are...
-
Amylin Pharmaceuticals, Inc. is a
biopharmaceutical founded in 1987 that was
based in San Diego, California. The
company was
engaged in the discovery,...
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Cagrilintide is a long-acting
analogue of
amylin. It is
being tested to
treat obesity and type 2
diabetes by
itself and in
combination with semaglutide...
- Cagrilintide/semaglutide,
marketed as CagriSema, is a
combination of cagrilintide, a dual
amylin and
calcitonin receptor agonist, and semaglutide, a GLP-1 agonist. It is...
- of
Langerhans responsible for the
production and
release of
insulin and
amylin.
Constituting ~50–70% of
cells in
human islets, beta
cells play a vital...
-
Petrelintide (development name ZP8396) is an
amylin analogue dosed once w****ly,
developed by
Zealand Pharma for the
treatment of type 2
diabetes and obesity...
-
multimeric amylin receptors AMY1 (CT + RAMP1), AMY2 (CT + RAMP2), and AMY3 (CT+ RAMP3).
Preclinical studies have
suggested that dual
amylin and calcitonin...
- (trade name Symlin) is an
injectable amylin analogue drug for
diabetes (both type 1 and 2),
developed by
Amylin Pharmaceuticals (now a
wholly owned subsidiary...
