-
cyanide in the
presence of ammonia. The
condensation reaction yields an α-
aminonitrile,
which is
subsequently hydrolyzed to give the
desired amino acid. The...
- the Cook-Heilbron synthesis,
thiazoles arise by the
condensation of α-
aminonitrile with
carbon disulfide.
Thiazoles can be
accessed by
acylation of 2-aminothiolates...
- the
hydrophobic air-water
interface and a
novel "sulfide-mediated α-
aminonitrile ligation" scheme,
where amino acid
precursors come
together to form peptides...
-
imine is
attacked by the
isocyanide to form the
aminonitrile.
Nucleophilic addition of
aminonitrile to CO2
leads to cyano-carbamic acid,
which undergoes...
- of imines, most of the
reactions were
complete within 1 h
affording aminonitriles in
quantitative yield.
Kaskel and
coworkers carried out
similar cyanosilylation...
- metal–cyanide complexes.
Reaction with
ketones and
aldehydes yield aminonitriles, as in the
first step of the
Strecker amino acid synthesis: NH4CN +...
-
metal in tert-butanol) or by
fusion of a
nitrile in KOH. Similarly, α-
aminonitriles can be
decyanated with
other reducing agents such as
lithium aluminium...
-
acrylonitrile and
various tosyl imines to
afford functionalized α-methylene-β-
aminonitriles (75-98% yield, 76-98% ee).
Silver acetate is
required to
activate the...
- the
formation of 5-aminothiazoles
through the
chemical reaction of α-
aminonitriles or
aminocyanoacetates with dithioacids,
carbon disulphide,
carbon oxysulfide...
-
Opatz T,
Ferenc D (September 2006). "Preparation of
indoles from alpha-
aminonitriles: A
short synthesis of FGIN-1-27".
Organic Letters. 8 (20): 4473–5. doi:10...
