-
Acadesine (INN), also
known as 5-
aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, AICA-riboside, and AICAR, is an AMP-activated
protein kinase activator...
- 5-
Aminoimidazole-4-carboxamide
ribonucleotide (AICAR) is an
intermediate in the
generation of
inosine monophosphate.
AICAR is an
analog of
adenosine monophosphate...
- (1992). "Preparation,
structure and
addition reactions of 4- and 5-
aminoimidazoles".
Journal of the
Chemical Society,
Perkin Transactions 1 (21): 2779–2788...
- 5′-Phosphoribosyl-4-carboxy-5-
aminoimidazole (or CAIR) is an
intermediate in the
formation of purines. It is
formed by
phosphoribosylaminoimidazole carboxylase...
- The
conversion of ATP, L-aspartate, and 5-
aminoimidazole-4-carboxyribonucleotide (CAIR) to 5-
aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide,...
- 5'-phosphoribosyl-5-
aminoimidazole ("AIR") into 5'-phosphoribosyl-4-carboxy-5-
aminoimidazole ("CAIR") as
described in the reaction: 5-
aminoimidazole ribonucleotide...
-
inhibits the
enzyme thymidylate synthase, but also has
effects on DHFR,
aminoimidazole carboxamide ribonucleotide formyltransferase and
glycinamide ribonucleotide...
- use S-adenosyl
methionine as a cofactor. The
starting material is 5-
aminoimidazole ribotide,
which undergoes a
rearrangement reaction via
radical intermediates...
-
removal of a
water molecule,
forming the 5-membered
imidazole ring 5-
aminoimidazole ribonucleotide (AIR). N5-CAIR
synthetase transfers a
carboxyl group...
- 4-
aminoimidazole + H2O ⇌ {\displaystyle \rightleftharpoons }
unidentified product + NH3 Thus, the two
substrates of this
enzyme are 4-
aminoimidazole and...
