-
Aminocoumarin is a
class of
antibiotics that act by an
inhibition of the DNA
gyrase enzyme involved in the cell
division in bacteria. They are derived...
- Novobiocin, also
known as albamycin, is an
aminocoumarin antibiotic that is
produced by the
actinomycete Streptomyces niveus,
which has
recently been...
-
isolated from soil in the
United States.
Streptomyces niveus produces the
aminocoumarin antibiotic novobiocin and the
compounds nivetetracyclate A and nivetetracyclate...
- (nm) Em (nm) MW
Notes Hydroxycoumarin 325 386 331
Succinimidyl ester Aminocoumarin 350 445 330
Succinimidyl ester Methoxycoumarin 360 410 317 Succinimidyl...
-
Coumermycin A1 is an
aminocoumarin. Its main
target is the
ATPase site of the DNA
gyrase GyrB subunit.
Chemically induced dimerization Heide L (2009)...
-
class of
TopII antibiotics but
differ from
aminocoumarins in that they are
composed of both
aminocoumarins and a
polyketide element. They also inhibit...
- acid‡
Pipemidic acid‡
Piromidic acid‡ Rosoxacin‡
Fluoroquinolones Newer non-fluorinated
Nemonoxacin Ozenoxacin Related (DG)
Aminocoumarins: Novobiocin...
- and it is
hoped that some of
these will
replace FQs in the ****ure.
Aminocoumarins (Fig. 6), such as novobiocin,
clorobiocin and
coumermycin A1, are natural...
- antibiotics. Two
classes of
antibiotics that
inhibit gyrase are: The
aminocoumarins (including
novobiocin and
Coumermycin A1),
which work by competitive...
-
Clorobiocin is an
aminocoumarin antibacterial that
inhibits the
enzyme DNA gyrase. [1], http://www.drugbank.ca/drugs/DB03966.
Pojer F,
Wemakor E, Kammerer...
