- Methotrexate,
formerly known as
amethopterin, is a
chemotherapy agent and immune-system suppressant. It is used to
treat cancer,
autoimmune diseases, and...
-
although this has been
called into
question (see its article) Methotrexate/
amethopterin and its
novel analogues pemetrexed, edatrexate, pralatrexate, nolatrexed...
-
regimen developed by
Freireich and Frei was a
combination of vincristine,
amethopterin, mercaptopurine, and prednisone. Now,
other combinations and
doses that...
- Hair
Roots of the
Human Scalp and
Morphologic Changes Therein Following Amethopterin Therapy.
Journal of
investigative dermatology, 29(3), 197–204. "Caution:...
- 1964 – VAMP
regimen combination therapy,
consisting of: vincristine,
amethopterin, 6-mercaptopurine, and prednisone,
induces long-term
remissions in juvenile...
- then
working at
Lederle Laboratories) to
supply aminopterin and
later amethopterin (methotrexate) to
conduct trials on to
children with leukemia, a diagnosis...
- (February 1958). "Inhibition of
dihydrofolic reductase by
aminopterin and
amethopterin".
Proceedings of the
Society for
Experimental Biology and Medicine. 97...
- of
Lederle Laboratories.
These analogues —
first aminopterin and then
amethopterin (now methotrexate) were
antagonistic to
folic acid, and
blocked the function...
- ****ociation of a
Specific Chromosome with
Dihydrofolate Reductase Activity in
Amethopterin-treated sublines".
Cancer Research. 25: 246–257. PMID 14264058. Biedler...
- anti-folate agents.
Hutchison and
Sirotnak found that
resistance to
amethopterin in L1210
leukemia cells was due to an
alteration in drug
uptake and postulated...
