- In the
fields of
biochemistry and
pharmacology an
allosteric regulator (or
allosteric modulator) is a
substance that
binds to a site on an
enzyme or receptor...
- In
pharmacology and biochemistry,
allosteric modulators are a
group of
substances that bind to a
receptor to
change that receptor's
response to stimuli...
-
Allosteric enzymes are
enzymes that
change their conformational ensemble upon
binding of an
effector (
allosteric modulator)
which results in an apparent...
- the
complex with
strongly allosteric behaviour with
respect to its substrates. The
enzyme is an
archetypal example of
allosteric modulation of fine control...
-
Allosteric serotonin reuptake inhibitor is a type of
selective serotonin reuptake inhibitor (SSRI).
Evidence of the
allosteric action of
escitalopram on...
-
Antagonists mediate their effects by
binding to the
active site or to the
allosteric site on a receptor, or they may
interact at
unique binding sites not normally...
- PMID 28419415.
Burford NT,
Traynor JR, Alt A (January 2015). "Positive
allosteric modulators of the μ-opioid receptor: a
novel approach for ****ure pain...
-
reaction rate of the enzyme. In this way,
allosteric interactions can
either inhibit or
activate enzymes.
Allosteric interactions with
metabolites upstream...
- protein–protein interaction),
enzyme substrates,
second messengers, hormones, or
allosteric modulators. The
binding event is often, but not always,
accompanied by...
-
consensus among researchers is that
allosteric inhibitors may
provide a more
regulatable anticoagulant. Some of the
allosteric inhibitors discovered include...
