-
Allopregnanolone is a
naturally occurring neurosteroid which is made in the body from the
hormone progesterone. As a medication,
allopregnanolone is referred...
- injury. Ganaxolone, a
synthetic analog of the
endogenous neurosteroid allopregnanolone, is
under investigation for the
treatment of epilepsy.
Based on differences...
-
inhibits the
production of
several anticonvulsant neurosteroids including allopregnanolone, androstanediol, and tetrahydrodeoxycorticosterone.
Adverse effects...
- from progesterone. It is also an
intermediate in the
synthesis of
allopregnanolone and
isopregnanolone from progesterone. 5α-DHP is
metabolized by the...
-
names LYT-300, SPT-300) is an
orally active prodrug of
brexanolone (
allopregnanolone)
which is
under development for the
treatment of
anxiety disorders...
- have
measured lower levels of
allopregnanolone ****ociated with
postpartum depression, and
identified lower allopregnanolone levels as a risk
factor for...
- include:
Progestogens Pregnenolone →
Progesterone →
Allopregnanedione →
Allopregnanolone 17α-Hydroxypregnenolone → 17α-Hydroxyprogesterone
Androgens Dehydroepiandrosterone...
- 5α-THP), is an
endogenous neurosteroid and a
natural 3β-epimer of
allopregnanolone. It has been
reported to act as a subunit-selective
negative allosteric...
- is
produced in the body from progesterone. It is
closely related to
allopregnanolone,
which has
similar properties.
Pregnanolone is a
positive allosteric...
- a
precursor for
other neurosteroids such as
pregnenolone sulfate,
allopregnanolone, and
pregnanolone and for
steroid hormones.
Pregnenolone has low bioavailability...
