- 1-demethylase EC 1.14.13.179:
methylxanthine N 3-demethylase EC 1.14.13.180:
aklavinone 12-hydroxylase EC 1.14.13.181: 13-deoxydaunorubicin
hydroxylase EC 1.14...
- ring to a 17-OH
group to give
aklavinone (9). This
introduces a new
chiral center and
NADPH is a cofactor. Dnr F,
aklavinone-11-hydroxylase, is a FAD monooxygenase...
- Kristiina; Hakala, Juha; Mäntsälä,
Pekka (February 1999). "Characterization of
aklavinone-11-hydroxylase from
Streptomyces purpurascens".
Biochimica et Biophysica...
- TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase EC 2.4.1.326:
aklavinone 7-L-rhodosaminyltransferase EC 2.4.1.327: aclacinomycin-T 2-deoxy-L-fucose...
- the
biosynthetic pathway. The
biosynthetic route is
similar to that of
aklavinone (the
aglycone core of most anthracyclines,
including doxorubicin), the...
