- In
eukaryotic cells, an
aggresome refers to an
aggregation of
misfolded proteins in the cell,
formed when the
protein degradation system of the cell is...
- were
shortened by mutations. Lewy
bodies are
believed to
represent an
aggresome response in the cell. When
misfolded proteins aggregate, or
clump together...
- some are not. Note the
following four examples: HDAC6 is ****ociated with
aggresomes.
Misfolded protein aggregates are
tagged by
ubiquitination and removed...
- rely on
cholesteryl esters derived from LDL.
Vimentin plays a role in
aggresome formation,
where it
forms a cage
surrounding a core of
aggregated protein...
- "The
cellular fate of
mutant rhodopsin:
quality control,
degradation and
aggresome formation".
Journal of Cell Science. 115 (Pt 14): 2907–2918. doi:10.1242/jcs...
-
endosome PML body late
endosome P-body phagop**** ****embly site
nucleoplasm aggresome autophagosome amphisome endoplasmic reticulum inclusion body lysosome...
-
autophagy in
macrophages is a p62-dependent type of
selective autophagy of
aggresome-like
induced structures (ALIS). Autophagy, 7: 29–31.
Fujita K, Xiao Q...
-
efficacy of
mammalian cells may be
limited by
epigenetic gene
silencing and
aggresome formation (recombinant
protein aggregation). For
mammalian cells, synthesised...
- overworked. In
mammalian cells,
these protein aggregates are
termed "
aggresomes" and they are
formed when the cell is diseased. This is
because aggregates...
-
reticulum stress response (ER stress)
Mitochondrial unfolded protein response Aggresome PERK
inhibitors Hetz C, Papa FR (January 2018). "The
Unfolded Protein...
