- ****ociated with the
development of arthritis.
Proteases capable of
degrading aggrecans are
called aggrecanases, and they are
members of the ADAM (A Disintegrin...
-
Aggrecan, the
major proteoglycan in cartilage, has 2316
amino acids...
- cells,
collagen fibrils, and
aggrecan, a
proteoglycan that
aggregates by
binding to hyaluronan.
Attached to each
aggrecan molecule are glycosaminoglycan...
-
differentiates into
chondroblasts and
begins secreting the
molecules (
aggrecan and
collagen type II) that form the
extracellular matrix. In all vertebrates...
-
Versican HS/CS
Testican Perlecan CS
Chondroitin sulfate proteoglycans:
Aggrecan Neurocan Brevican CD44 CSPG4 CSPG5
Platelet factor 4
Structural maintenance...
-
Versican HS/CS
Testican Perlecan CS
Chondroitin sulfate proteoglycans:
Aggrecan Neurocan Brevican CD44 CSPG4 CSPG5
Platelet factor 4
Structural maintenance...
-
include type I
collagen (sp1 site), type IX collagen,
vitamin D receptor,
aggrecan, asporin, MMP3, interleukin-1, and interleukin-6 polymorphisms. Mutation...
- glycoproteins,
collagen types II, IX, X, and XI, and the
proteoglycan aggrecan. the
components within the
extracellular matrix are
produced by the chondroblasts...
- cartilage,
where it is
present as a coat
around each cell (chondrocyte). When
aggrecan monomers bind to
hyaluronan in the
presence of HAPLN1 (hyaluronic acid...
-
Versican HS/CS
Testican Perlecan CS
Chondroitin sulfate proteoglycans:
Aggrecan Neurocan Brevican CD44 CSPG4 CSPG5
Platelet factor 4
Structural maintenance...
