-
Aggrecanases are
extracellular proteolytic enzymes that are
members of the
ADAMTS (A
Disintegrin And
Metalloprotease with
Thrombospondin Motifs) family...
-
Akeda K,
Miyamoto K, ****o T, An HS,
Masuda K (Nov 2007). "
Aggrecanases and
aggrecanase-generated
fragments in the
human intervertebral disc at early...
-
proteoglycans in
articular cartilage in osteoarthritis.
Which of
these aggrecanases is more
important in
cartilage degradation appears to be species-specific...
- activity,
mediated by
factors including matrix metalloproteinases and
aggrecanases.
Traumatic rupture or detachment: The
cartilage in the knee is frequently...
- ADAMTS-4
endopeptidase (EC 3.4.24.82,
aggrecanase-1) is an enzyme. This
enzyme catalyses the
following chemical reaction Glutamyl endopeptidase; bonds...
-
development of arthritis.
Proteases capable of
degrading aggrecans are
called aggrecanases, and they are
members of the ADAM (A
Disintegrin And Metalloprotease)...
-
dendritic cells in
spleen and
lymph nodes. Here,
cochlin is
cleaved by
aggrecanases and
secreted into
blood circulation during inflammation, contributing...
- Kurz B,
Sandy JD,
Grodzinsky AJ (February 2000). "Mannosamine
inhibits aggrecanase-mediated
changes in the
physical properties and
biochemical composition...
- 31;434(7033):648-52. Fosang,
Amanda J., and
Christopher B. Little. "Drug insight:
aggrecanases as
therapeutic targets for osteoarthritis."
Nature Clinical Practice...
-
cartilage from
patients with
osteoarthritis and
appears to
suppress ADAMTS4 (
aggrecanase) activity,
possibly leading to
cartilage cell (chondrocyte) cloning....
