Definition of Aggrecanase. Meaning of Aggrecanase. Synonyms of Aggrecanase

Here you will find one or more explanations in English for the word Aggrecanase. Also in the bottom left of the page several parts of wikipedia pages related to the word Aggrecanase and, of course, Aggrecanase synonyms and on the right images related to the word Aggrecanase.

Definition of Aggrecanase

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Meaning of Aggrecanase from wikipedia

- Aggrecanases are extracellular proteolytic enzymes that are members of the ADAMTS (A Disintegrin And Metalloprotease with Thrombospondin Motifs) family...
- encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. ADAMTS5 may also...
- proteoglycans in articular cartilage in osteoarthritis. Which of these aggrecanases is more important in cartilage degradation appears to be species-specific...
- Kurz B, Sandy JD, Grodzinsky AJ (February 2000). "Mannosamine inhibits aggrecanase-mediated changes in the physical properties and biochemical composition...
- ADAMTS-4 endopeptidase (EC 3.4.24.82, aggrecanase-1) is an enzyme. This enzyme catalyses the following chemical reaction Glutamyl endopeptidase; bonds...
- development of arthritis. Proteases capable of degrading aggrecans are called aggrecanases, and they are members of the ADAM (A Disintegrin And Metalloprotease)...
- activity, mediated by factors including matrix metalloproteinases and aggrecanases. Traumatic rupture or detachment: The cartilage in the knee is frequently...
- ISSN 1063-4584. Malfait AM, Tortorella MD (2019-09-17). "The "elusive DMOAD": Aggrecanase inhibition from laboratory to clinic". Clinical and Experimental Rheumatology...
- damage in arthritic disease. Her work showing that ADAMTS-5 is the major aggrecanase in mouse cartilage was published in the high-profile international journal...
- cartilage from patients with osteoarthritis and appears to suppress ADAMTS4 (aggrecanase) activity, possibly leading to cartilage cell (chondrocyte) cloning....