Definition of Aggrecanase. Meaning of Aggrecanase. Synonyms of Aggrecanase

Here you will find one or more explanations in English for the word Aggrecanase. Also in the bottom left of the page several parts of wikipedia pages related to the word Aggrecanase and, of course, Aggrecanase synonyms and on the right images related to the word Aggrecanase.

Definition of Aggrecanase

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Meaning of Aggrecanase from wikipedia

- Aggrecanases are extracellular proteolytic enzymes that are members of the ADAMTS (A Disintegrin And Metalloprotease with Thrombospondin Motifs) family...
- encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. ADAMTS5 may also...
- proteoglycans in articular cartilage in osteoarthritis. Which of these aggrecanases is more important in cartilage degradation appears to be species-specific...
- ADAMTS-4 endopeptidase (EC 3.4.24.82, aggrecanase-1) is an enzyme. This enzyme catalyses the following chemical reaction Glutamyl endopeptidase; bonds...
- activity, mediated by factors including matrix metalloproteinases and aggrecanases. Traumatic rupture or detachment: The cartilage in the knee is frequently...
- Kurz B, Sandy JD, Grodzinsky AJ (February 2000). "Mannosamine inhibits aggrecanase-mediated changes in the physical properties and biochemical composition...
- development of arthritis. Proteases capable of degrading aggrecans are called aggrecanases, and they are members of the ADAM (A Disintegrin And Metalloprotease)...
- (December 2000). "Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites". The Journal of Biological Chemistry...
- ISSN 1063-4584. Malfait AM, Tortorella MD (2019-09-17). "The "elusive DMOAD": Aggrecanase inhibition from laboratory to clinic". Clinical and Experimental Rheumatology...
- cartilage from patients with osteoarthritis and appears to suppress ADAMTS4 (aggrecanase) activity, possibly leading to cartilage cell (chondrocyte) cloning....