-
Acylureas (also
called N-
acylureas or ureides) are a
class of
chemical compounds formally derived from the
acylation of urea. A
subclass of
acylureas...
- allylisopropylacetylcarbamide, is a hypnotic/sedative drug of the
ureide (
acylurea)
group synthesized in 1926 by Hoffmann-La Roche.
Though it is not a barbiturate...
- and
carbromal (Horowitz, 1997). They are a
subfamily of the
ureides (
acylureas).
Apronal Horowitz, B., "Bromism from
Excessive Cola Consumption," Clinical...
- von
Mering on the
pharmacological properties of
certain open and
closed acylureas (then
called ureides). Led by the
impression that
hypnotic action appears...
-
alkoxycarbonylamino acid
symmetrical anhydrides:
Isolation of two N -
acylureas".
International Journal of
Peptide and
Protein Research. 43 (2): 184–189...
- wide
range of reactions,
including reaction with acyl
halides to form
acylureas,
coupling with
vinyl halides, and multi-component
condensation reaction...
-
acetylcarbromal and acetyladalin, is a
hypnotic and
sedative drug of the
ureide (
acylurea)
group discovered by
Bayer in 1917 that was
formerly marketed in the United...
-
Chlorphenacemide is
pharmaceutical drug of the
acylurea class used as an anticonvulsant.
Swinyard EA (1985). "Acetylurea Derivatives".
Antiepileptic Drugs...
- side-reaction is a 1,3-rearrangement of the O-acyl
intermediate to an N-
acylurea which is
unable to
further react with the alcohol. DMAP
suppresses this...
- concentration-independent
Metabolism Liver,
predominately via
hydrolysis of the
acylurea bond or the urea
moiety Elimination half-life 63–69
hours (estimated) Excretion...
