-
Aconitase (aconitate hydratase; EC 4.2.1.3) is an
enzyme that
catalyses the stereo-specific
isomerization of
citrate to
isocitrate via cis-aconitate in...
- is a
tricarboxylic acid. The
compound is an
inhibitor of the
enzyme aconitase and
therefore interferes with the
Krebs cycle.
Esters of propane-1,2,3-tricarboxylic...
- the
mechanism of
aconitase action.
Isotope scrambling experiments using tritium, deuterium, and 18O were
carried out on the
aconitase hydratase reaction...
- They have many
other functions including catalysis as
illustrated by
aconitase,
generation of
radicals as
illustrated by SAM-dependent enzymes, and as...
- to an
inhibition of the
enzyme aconitase (EC 4.2.1.3) by high
concentrations of
reactive oxygen species (ROS)
Aconitase catalyzes the
conversion of citrate...
-
presence of high iron concentrations,
aconitase functions as an
enzyme while at low iron concentration,
aconitase functions as an iron-responsive element-binding...
-
Aconitase 2,
mitochondrial is a
protein that in
humans is
encoded by the ACO2 gene. The
secondary structure of ACO2
consists of
numerous alternating alpha...
- with
acetyl CoA to form citrate.
Citrate then acts as the
substrate for
aconitase and is
converted into
aconitic acid. The
cycle ends with regeneration...
- cycle.
Isocitrate is
formed from
citrate with the help of the
enzyme aconitase, and is
acted upon by
isocitrate dehydrogenase.
Isocitric acid is commonly...
- irreversible,
extends the 4C
oxaloacetate to a 6C
molecule 1
Dehydration Citrate Aconitase cis-Aconitate + H2O
reversible isomerisation 2
Hydration cis-Aconitate...
