-
cysteine residue (see schematic). In
comparison with its
acid derivative, iodoacetate,
iodoacetamide reacts substantially faster. This
observation appears...
-
negatively charged carboxyl-group of the
iodoacetic acid is the
reason for the
increased activity of
iodoacetamide.
Several studies have
shown iodoacetate has...
- nucleophile,
which will
react with soft electrophiles, such as
maleimides and
iodoacetamides (shown in the
first two
reactions in
Figure 2 below). As a result, a...
-
Latent autoimmune diabetes Interrupted aortic arch, a
medical condition Iodoacetamide, an
alkylating agent Isoamyl alcohol, a
common name for 3-Methylbutan-1-ol...
-
organoiodine compounds are
stronger alkylating agents. For example,
iodoacetamide and
iodoacetic acid denature proteins by
irreversibly alkylating cysteine residues...
-
crucial to the enzyme's
catalytic function. The
residue is
alkylated by
iodoacetamide in both the
cytosolic and
mitochondrial isozymes, with modifications...
-
groups methanethiosulfonate, maleimide, and
iodoacetamide,
creating a
covalent bond with the
amino acid Cys. Spin
labels are a
unique molecular reporter...
-
studied as an
anticancer drug.
Ethylene glycol Iodoacetic acid Ethyl iodoacetate Iodoacetamide "Enzyme
Alterable Alkylating Agents. VI. Synthesis, Chemical...
-
carbodiimide and
subsequent coupling with amine);
thiol (e.g. via
maleimide or
iodoacetamides);
azide (e.g. via
click chemistry with
terminal alkyne); or non-specificately...
- pneumonia. In
Escherichia coli, platensimycin, thiolactomycin, and
iodoacetamide are also
known inhibitors.
Optimal pH
range will vary
depending on the...
