-
These are
classified as slow
acetylators,
while the wild-type NAT2 is
classified as a fast
acetylator. Slow
acetylators tend to be ****ociated with drug...
- Pharmacogenomics,
often abbreviated "PGx," is the
study of the role of the
genome in drug response. Its name (pharmaco- + genomics)
reflects its combining...
-
which human po****tions
segregate into rapid, intermediate, and slow
acetylator phenotypes.
Polymorphisms in NAT2 are also ****ociated with
higher incidences...
-
group of
people who
acetylate slowly (slow
acetylators) and
those who
acetylate quickly (rapid
acetylators),
split roughly 50:50 in the po****tion of...
- than others. Hence, the half-life is bimodal, with "slow
acetylators" and "fast
acetylators". A
graph of
number of
people versus time
shows peaks at one...
-
phenotypes that
result from the
acetylation process,
namely the slow and
rapid acetylator.
Procainamide can also be
oxidized by the
cytochrome P-450 to a reactive...
- with DIL were slow
acetylators. In addition,
these patients had more
hydralazine metabolites in
their urine than fast
acetylators.
These metabolites (byproducts...
-
salicylazosulfapyridine therapy and the
relation with drug
metabolism and
acetylator phenotype". The New
England Journal of Medicine. 289 (10): 491–495. doi:10...
-
Reactions involving acetylation are
influenced by
genetic variance: the
acetylator phenotype. The
toxicological response to
isoniazid (and thus iproniazid)...
-
Individuals can be
classified as
either rapid or slow N-oxidizers and O-
acetylators by ****essing CYP1A2 and NAT2 activities.
Individuals with the
rapid phenotype...
