-
Acetoacetyl CoA is the
precursor of HMG-CoA in the
mevalonate pathway,
which is
essential for
cholesterol biosynthesis. It also
takes a
similar role in...
- and acetoacetate: −O2CCH2−C(Me)(OH)−CH2C(O)−CoA → −O2CCH2−Ac + Ac−CoA
Acetoacetyl-CoA can come from beta
oxidation of butyryl-CoA: Et−CH2C(O)−CoA + 2NAD+...
-
acetyltransferases (ACAT), are
enzymes which convert two
units of acetyl-CoA to
acetoacetyl CoA in the
mevalonate pathway.
Thiolases are
ubiquitous enzymes that...
-
enzyme which catalyzes the
reaction in
which acetyl-CoA
condenses with
acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). This
reaction comprises...
- Acetyl-CoA acetyltransferase, mitochondrial, also
known as
acetoacetyl-CoA thiolase, is an
enzyme that in
humans is
encoded by the ACAT1 (Acetyl-Coenzyme...
-
mevalonate and
ketogenesis pathways. It is
formed from
acetyl CoA and
acetoacetyl CoA by HMG-CoA synthase. The
research of
Minor J. Coon and
Bimal Kumar...
- \rightleftharpoons } CoA +
acetoacetyl-CoA Hence, this
enzyme has one substrate, acetyl-CoA, and two products, CoA and
acetoacetyl-CoA. Acetyl-CoA C-acetyltransferase...
- acetyl-CoA. The
first step
condenses two acetyl-CoA
molecules to
yield acetoacetyl-CoA. This is
followed by a
second condensation to form HMG-CoA (3-hydroxy-3-...
-
names 3-oxothiolase deficiency,
Mitochondrial acetoacetyl-coenzyme A
thiolase deficiency, Alpha-methyl-
acetoacetyl-CoA
thiolase deficiency Isoleucine...
-
occurs after acetoacetyl CoA formation. This
intermediate then
takes two
possible pathways:
acetoacetyl CoA →
acetoacetate →
acetone acetoacetyl CoA → butyryl...
