- Like ADAMs, the name of the
ADAMTS family refers to its
disintegrin and
metalloproteinase activity, and in the case of
ADAMTS, the
presence of a thrombospondin...
- cases. Genomically, ADAMTS13
shares many
properties with the 19
member ADAMTS family, all of
which are
characterised by a
protease domain (the part that...
- the von
Willebrand factor-cleaving
protease ADAMTS-13. The
plasmapheresis procedure also adds
active ADAMTS-13
protease proteins to the patient, restoring...
-
ADAMTS-4
endopeptidase (EC 3.4.24.82, aggrecanase-1) is an enzyme. This
enzyme catalyses the
following chemical reaction Glutamyl endopeptidase; bonds...
-
humans is
encoded by the ADAMTS8 gene. This gene
encodes a
member of the
ADAMTS (a
disintegrin and
metalloproteinase with
thrombospondin motifs) protein...
- a
disintegrin and
metalloproteinase domain with
throbospondin motifs (
ADAMTS), and
cysteine and
serine proteases are
involved in angiogenesis. This article...
- with
thrombospondin type 1 motif".
Verma P,
Dalal K (Dec 2011). "
ADAMTS-4 and
ADAMTS-5: key
enzymes in osteoarthritis".
Journal of
Cellular Biochemistry...
- Upshaw–Schulman syndrome.
People with this
syndrome generally have 5–10% of
normal ADAMTS-13 activity. A 2024
study suggested that
hereditary TTP is underdiagnosed...
-
Pharmacokinetics and
Pharmacodynamics of
Single Ascending Doses of the Anti-
ADAMTS-5 Nanobody®, M6495, in
Healthy Male Subjects: A
Phase I, Placebo-Controlled...
- 1056/NEJMoa022831. PMID 12878741.
Moake JL (January 2004). "von
Willebrand factor,
ADAMTS-13, and
thrombotic thrombocytopenic purpura".
Seminars in Hematology. 41...
